# LONGEVITY / What we know about extending healthspan

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Category: Future
Slides: 13
Updated: 2026-05-15T22:19:38.345Z
Tags: catalog, future, longevity

## Summary

A clinical-trial style tour of the hallmarks of aging, the interventions actually being tested in humans, and the honest limits of what biology will allow. Key sections include: LONGEVITY / What we know about extending healthspan; From 30 to 80 in a century — and almost none of it from anti-aging.; Lifespan vs healthspan . The goal isn't more years. It's more good years.; The Hallmarks of Aging López-Otín et al., 2013 · updated 2023; Caloric restriction moderate evidence; mTOR & rapamycin moderate evidence; Senolytics early human; Yamanaka factors preclinical Resetting the epigenetic clock; Metformin — the boring candidate moderate evidence; Exercise strongest evidence The intervention with no equal in 2026..

## Slide Outline

1. LONGEVITY / What we know about extending healthspan
2. From 30 to 80 in a century — and almost none of it from anti-aging.
3. Lifespan vs healthspan . The goal isn't more years. It's more good years.
4. The Hallmarks of Aging López-Otín et al., 2013 · updated 2023
5. Caloric restriction moderate evidence
6. mTOR & rapamycin moderate evidence
7. Senolytics early human
8. Yamanaka factors preclinical Resetting the epigenetic clock
9. Metformin — the boring candidate moderate evidence
10. Exercise strongest evidence The intervention with no equal in 2026.
11. Sleep, diet, stress Foundational. Multipliers on everything else.
12. What's actually decades away. What's available today.
13. Where to go next.

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