# Aging — The Mechanics of Getting Older

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Category: Health
Slides: 13
Updated: 2026-05-15T22:19:38.777Z
Tags: catalog, health, aging

## Summary

Average life expectancy in 1900 hovered around the mid-40s. Today it sits near 79 in high-income countries — but the gain came mostly from preventing infants and young adults from dying, not from extending old age. Key sections include: AGING / The mechanics of getting older; We almost doubled the human lifespan in a century.; The Hayflick limit, 1961.; The hallmarks of aging.; Genomic instability.; Telomere attrition.; Epigenetic alterations.; Mitochondrial dysfunction.; Cellular senescence — the zombie cells.; Stem cell exhaustion..

## Slide Outline

1. AGING / The mechanics of getting older
2. We almost doubled the human lifespan in a century.
3. The Hayflick limit, 1961.
4. The hallmarks of aging.
5. Genomic instability.
6. Telomere attrition.
7. Epigenetic alterations.
8. Mitochondrial dysfunction.
9. Cellular senescence — the zombie cells.
10. Stem cell exhaustion.
11. The blue-zones critique.
12. Plausible interventions, ranked by evidence.
13. References & further viewing.

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